Cellular and Molecular Medicine Research


Editor-in-Chief
Consolato M. Sergi
, MD, PhD, MPH, FRCPC, FCAP, FACSc
Chief, Division of Anatomical Pathology
Professor of Pathology & Pediatrics, Children’s Hospital of Eastern Ontario (CHEO), University of Ottawa, Canada
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Frequency: Quarterly
Journal access: Open Access
Article publishing charge (APC): None
Journal scope: Medical research from cellular and molecular levels,
these include the basic medical research and the technological research related to the diseases pathogenesis, diagnosis, treatment, and prevention. Published quarterly both in print and online, is an international, open access and peer-reviewed journal.

Journal archiving and digital preservation: Portico

 

Highlights

  • Formononetin: A Phytoestrogen and Isoflavone, Relaxes Guinea Pig Gallbladder Strips

    Formononetin, a phytoestrogen and isoflavone, is present in red clover and several types of beans. It relaxes vascular smooth muscle and prostate smooth muscle. The purpose of this study was to determine if formononetin had an effect of gallbladder motility. An in vitro technique was used to determine which system mediated the relaxation.

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  • Stress, Autoimmunity and Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease

    Chronic obstructive pulmonary disease (COPD) includes several clinical syndromes, most notably emphysema and chronic bronchitis, respiratory bronchiolitis, asthma and COPD overlap syndrome (ACOS), COPD and obstructive sleep apnea (OSA) overlap syndrome and combination of pulmonary fibrosis and emphysema (CPFE).

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  • Calcitonin Gene-Related Peptide Enhances the Expression of Signaling Molecules of the Wnt 7b/Beta-Catenin Pathway in Rat Type II Alveolar Epithelial Cells Under Hyperoxia

    Hyperoxic lung injury is characterized by epithelial cell death and leukocyte infiltration/inflammation in the lung. Calcitonin gene-related peptide (CGRP) has been shown to improve survival of lung epithelial cells and reduce hyperoxic lung injury in rats.

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  • WNIN Mutant Obese Rats Develop Acute Pancreatitis With the Enhanced Inflammatory Milieu

    WNIN/Gr-Ob rats demonstrate features of metabolic syndrome that include obesity, insulin resistance, impaired glucose tolerance, and hyperinsulinemia. The impetus obtained from earlier studies on these rats demonstrates an inflammatory milieu peaking between 6 and 9 months of age in adipose, pancreas, and bone marrow/mesenchymal stem cells.

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Viewpoints

Advances in Molecular Perspectives of Tumor-Initiating Cells on Cancer Therapy

Cancer stem cells (CSCs) known as tumorigenic cells are biologically distinct from diverse subpopulations. Cancer cell heterogeneity readily leads to development of drug resistance and tolerance to treatment. CSC hypothesis has resulted in incredible impact on the understanding and insight into tumor biology. More importantly, advances in molecular perspectives have achieved in the recent decades although many aspects of this hypothesis remain speculative and are still evolving. Full Text...


Featured

 

 


Featured

 

Calcitonin Gene-Related Peptide Enhances the Expression of Signaling Molecules of the Wnt 7b/Beta-Catenin Pathway in Rat Type II Alveolar Epithelial Cells Under Hyperoxia
Hyperoxic lung injury is characterized by epithelial cell death and leukocyte infiltration/inflammation in the lung. Calcitonin gene-related peptide (CGRP) has been shown to improve survival of lung epithelial cells and reduce hyperoxic lung injury in rats. However, the mechanism of CGRP protective activity is not completely understood.
Full Text

WNIN Mutant Obese Rats Develop Acute Pancreatitis With the Enhanced Inflammatory Milieu
WNIN Mutant Obese Rats Develop Acute Pancreatitis With the Enhanced Inflammatory Milieu
WNIN/Gr-Ob rats demonstrate features of metabolic syndrome that include obesity, insulin resistance, impaired glucose tolerance, and hyperinsulinemia. The impetus obtained from earlier studies on these rats demonstrates an inflammatory milieu peaking between 6 and 9 months of age in adipose, pancreas, and bone marrow/mesenchymal stem cells. Full Text


Current Issue


Vol. 1, No. 2, Sept 2017

Table of Contents

Review

Stress, Autoimmunity and Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease Abstract HTML PDF
Alcibey Alvarado 33-43
doi: https://doi.org/10.14740/cmmr17e
Recent Advances in Characterization of Pre-Leukemic/Leukemic Stem Cells in Acute Myeloid Leukemia Abstract HTML PDF
Liqing Jin, Licun Wu 44-51
doi: https://doi.org/10.14740/cmmr18e

Original Article

Formononetin: A Phytoestrogen and Isoflavone, Relaxes Guinea Pig Gallbladder Strips Abstract HTML PDF
Loren W. Kline, Edward Karpinski 52-58
doi: https://doi.org/10.14740/cmmr16e
 

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Cellular and Molecular Medicine Research, quarterly, ISSN pending (print), ISSN pending (online), published by Elmer Press Inc.                     
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